Endocrine Abstracts

Background and aim of study: Endocrinologists play a central role in the gender affirming process that transgender people chose to undergo, and may be ill-prepared to recognize and manage psychologic difficulties that accompany gender dysphoria. We sought to characterize the patient population currently under our care with respect to their mental health, and to address the question of possible differences between transwomen (TW) and transmen (TM).Methods...

Background: The standard approach for Gender-Affirming Hormone Therapy (GAHT) of transgender women (TW) in Israel is oral estradiol (OE) combined with the potent anti-androgen cyproterone acetate (CA). Recently, many of our non-binary patients have requested sublingual estradiol (SLE) without CA, under the unproven belief it preserves erectile function, and does not induce depression. Preliminary data in a few subjects, who self-practiced this approach, suggested it also maint...

Background: Although successful pregnancies carried by transgender men have been reported, long-term effects of testosterone therapy on fertility remain unknown.Aims: To study markers of ovarian reserve during testosterone therapy.Methods: Prospective open-label study of transgender men prior and during treatment with testosterone. Sampling was conducted at baseline and 12 months after treatment initiation.Ma...

Background: Various components of metabolic syndrome (MS) significantly increase the risk of thyroid cancer (TC). Moreover, thyroid cancer survivors (TCS) are at increased risk of new components of MS (MSC). The role of thyroid function in this context has not yet been determined. We investigated changes in selected MSC and their association with thyroid function during a two-year follow-up among TCS.Materials and Methods: This retrospective, nested case...

As optimal postoperative management of patients with clinically nonfunctioning pituitary adenomas (NFPA) is a matter of debate, the role of dopamine agonist (DA) therapy in this clinical setting was evaluated.Methods: Retrospective analysis of prospectively collected data was conducted at two pituitary referral centrer with different standard practices for post-operative management of NFPA: DA therapy or conservative follow up. Dopamine receptor 2 (D2R) ...

Background: The BSRTC aimed to standardize thyroid cytopathology reporting while enabling stratification of risk of malignancy (ROM) in thyroid nodules. Observational studies have demonstrated varying ROM for the Bethesda III and IV categories, further affected by the recent exemption of NIFTP. Finally, molecular testing is becoming a reasonable alternative for evaluating ROM in categories III and IV.Objective: To retrospectively establish the use of Bet...